Categorized Test Menu

• Histopathology
• Immunohistochemistry
• In-situ Hybridization

EBER
EGFR
Her2Neu Dual ISH
Kappa
Lambda
MDM2
MET
MYC
PIK3CA
PTEN
TOP2A
U6

• Immunofluorescence
• Cytopathology

• General Chemistry
• Hematology
• Flow Cytometry
• Microbiology
• Urinalysis
• Allergy Testing
• Hormone Testing
• General Immunology

ALK (D5F3) CDx Qualitative Immunohistochemical Assay:

Integrated Cellular and Molecular Diagnostics (ICMD) is proud to offer the ALK (D5F3) CDx immunohistochemical assay by Ventana. This companion diagnostic assay is the only FDA-approved qualitative immunohistochemical assay for ALK overexpression and is used as an aid in identifying patients with non-small cell lung cancer (NSCLC) who may be eligible for treatment with Xalkori (crizotinib).

BioFire:

Integrated Cellular and Molecular Diagnostics (ICMD) utilizes this groundbreaking, ultra-sensitive and specific multiplex PCR system for rapid diagnosis of gastrointestinal, upper respiratory, bloodborne, and CNS pathogens (see full list of detectable pathogens below). BioFire is FDA approved and compared to its competitors, identifies the largest number of viral, bacterial, fungal, and parasitic microbes all in approximately one hour. We are proud to offer this premier, rapid molecular test for our outpatient and inpatient providers. Diagnose infectious diseases for your patients and start treatment the same day. Learn more by visiting www.biofiredx.com.

BioFire Gastrointestinal Panel: Bacteria – Campylobacter (jejuni, coli and upsaliensis), Clostridium difficile (toxin A/B), Plesiomonas shigelloides, Salmonella, Yersinia enterocolitica, Vibrio (parahaemolyticus, vulnificus and cholera), Enteroaggregative E. coli (EAEC), Enteropathogenic E. coli (EPEC), Enterotoxigenic E. coli (ETEC) lt/st, Shiga-like toxin-producing E. coli (STEC) stx1/stx2 E. coli O157, Shigella/Enteroinvasive E. coli (EiEC). Parasites – Cryptosporidium, Cyclospora cayetanensis, Entamoeba histolytica, Giardia lamblia. Viruses – Adenovirus F40/41, Astrovirus, Norovirus GI/GII, Rotavirus A, Sapovirus (I, II, IV and V).

BioFire Respiratory Panel: Bacteria – Bordetella pertussis, Chlamydophila pneumoniae, Mycoplasma pneumoniae. Viruses – Adenovirus, Coronavirus HKU1, Coronavirus NL63, Coronavirus 229E, Coronavirus OC43, Human Metapneumovirus, Human Rhinovirus/Enterovirus, Influenza A, Influenza A/H1, Influenza A/H3, Influenza A/H1-2009, Influenza B, Parainfluenza Virus 1, Parainfluenza Virus 2, Parainfluenza Virus 3, Parainfluenza Virus 4, Respiratory Syncytial Virus.

BioFire Blood Culture Identification Panel: Gram-Positive Bacteria – Enterococcus, Listeria monocytogenes, Staphylococcus (Staphylococcus aureus), Streptococcus (Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus pneumoniae). Gram-Negative Bacteria – Acinetobacter baumannii, Haemophilus influenzae, Neisseria meningitidis, Pseudomonas aeruginosa, Enterobacteriaceae (Enterobacter cloacae complex, Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, Proteus, Serratia marcescens). Yeast – Candida albicans, Candida glabrata, Candida krusei, Candida parapsilosis, Candida tropicalis. Antibiotic Resistance – mecA, vanA/B, KPC.

BioFire Meningitis/Encephalitis Panel (Under Development): Bacteria – Escherichia coli K1, Haemophilus influenzae, Listeria monocytogenes, Neisseria meningitidis, Streptococcus agalactiae, Streptococcus pneumoniae. Viruses – Cytomegalovirus (CMV), Enterovirus, Epstein-Barr virus (EBV), Herpes simplex virus 1 (HSV-1), Herpes simplex virus 2 (HSV-2), Human herpesvirus 6 (HHV-6), Human parechovirus, Varicella zoster virus (VZV). Yeast – Cryptococcus gattii, Cryptococcus neoformans.

Next Generation Sequencing:

Pan-Cancer Mutation Panel

ABL1          AKT1          ALK          APC          ATM          BRAF          CDH1

CSF1R      CTNNB1     EGFR        Her2       ERBB4       FBXW7       FGFR1

FGFR2      FLT3           GNA11     GNAQ     GNAS         HRAS          IDH1

JAK2         JAK3            KDR         KIT          KRAS         MET          MLH1

MPL          NOTCH1    NPM1     NRAS       PDGFRA    PIK3CA    PTEN

PTPN11   RET            SMAD4   SMARCB1   SMO       SRC           TP53

Pan-RAS Mutation

High Resolution Chromosomal Microarray Analysis (CMA)

Molecular Oncology Assays:

Prosigna Breast Cancer Prognostic Gene Signature Assay: Integrated Cellular and Molecular Diagnostics (ICMD), with the support of Thomas Jefferson University, is proud to be one of the few laboratories in the nation able to provide our clients with the latest in breast cancer genomics by offering Prosigna. This FDA approved assay is vital for assessing risk in early-stage breast cancer. Learn more by visiting www.prosigna.com.
KRAS codon 12/13 mutation analysis, by DNA sequencing
NRAS codon 61 mutation analysis, by DNA sequencing
BRAF codon 600/601 mutation analysis, by DNA sequencing
BRAF codon 600 mutation analysis, by PCR (FDA approved as companion diagnostic for melanoma)
EGFR analysis for mutations in codons 719/768/790/858/861, deletions in exon 19, and insertions in exon 20, by DNA sequencing
JAK2 codon 617 mutation analysis, by PCR
NPM1 exon 12 insertion/deletion analysis
Bone Marrow Engraftment Assay quantifies level of recipient DNA
Microsatellite Instability Analysis identifies mismatch repair defects by testing for length changes in DNA microsatellite repeats
Clonal Rearrangement of the IGH gene, by PCR
Clonal Rearrangements of the T cell Receptor Gamma Gene, by PCR

Molecular Infectious Disease Assays:

MRSA Screening
Respiratory Virus Panel
HIV-1 RNA, Quantitative PCR
Hepatitis B, Quantitative PCR
Hepatitis C, Quantitative PCR
HCV Viral Load with Genotype
BK Virus, Quantitative PCR
CMV, Quantitative PCR
CMV, Semi-Quantitative for Non-Blood Specimens
Chlamydia and Gonorrhea, Qualitative PCR
Chlamydia and Gonorrhea, Qualitative PCR for ThinPrep
High-Risk HPV, Qualitative

Cytogenetic analysis (BM, BC, LN, or Leukemia Blood)

Postnatal with reflex testing to chromosome microarray
Cancer

Fluorescence in situ hybridization (FISH)

Postnatal
Cancer

Highlights:

APL:  Rapid TAT for PML/RARA
Burkitt: Rapid TAT for MYC/IGH@

Plasma Cell Enrichment Testing for Plasma Cell Myeloma
Plasma Cell Myeloma

Novel Cocktail For Growing CLL Cultures

Solid Tumors:

Oligodendroglioma
Glioblastoma
Gastric Her2/neu
Liposarcoma
Non-small cell lung cancer
Urovysion: Bladder Cancer
Thyroid Cancer (In Process)

Disease Panels:

Acute Myeloid Leukemia Panel
Myelodysplastic Syndrome (MDS) Panel
Myeloproliferative Neoplasm Panel
Eosinophilia Panel
B-Acute Lymphoblastic Leukemia (ALL) Panel
T-Acute Lymphoblastic Leukemia (ALL) Panel
Chronic Lymphocytic Leukemia Panel
Lymphoma Panel
Plasma Cell Myeloma Panel

Plasma Cell Myeloma Panel on CD138 enriched cells by FISH